We are unlocking the potential of cryo-electron microscopy (cryo-EM) as a high-throughput structure determination technique for life sciences and drug discovery.
Cryo-EM is a recent Nobel Prize-winning technique for microscopy and 3D reconstruction of proteins and other biological molecules. A sample containing proteins and protein-ligand complexes is frozen in a thin film of ice and subsequently imaged in an electron microscope. The resulting microscopy data is analyzed via complex algorithms to identify the contents of the sample and solve the 3D atomic structures of the embedded protein molecules in their near-native states.
Novel technologies and algorithms applied to the cryo-EM field
Building Proteins in a Day
Scientific paper describing efficient 3D molecular structure estimation accelerated with GPUs.
Ab-initio reconstruction and rapid, high-resolution refinement released in cryoSPARC along with our Nature Methods paper.
Used by over 400 institutions, cryoSPARC v2 is a full-pipeline package for single-particle reconstruction.
The ability to resolve high-resolution structures in real-time during data collection at the microscope.