Enabling Cryo-EM for Life Science and Drug Discovery

We are unlocking the potential of cryo-electron microscopy (cryo-EM) as a high-throughput structure determination technique for life sciences and drug discovery.

What We Do

Computational Solutions
for Cryo-EM Image Analysis

Cryo-EM is a Nobel Prize-winning technique for microscopy and 3D reconstruction of proteins, protein-ligand complexes and other biological molecules. A sample containing the target of interest is frozen in a thin film of ice and subsequently imaged in an electron microscope. The resulting microscopy data is analyzed using our complex algorithms to identify the contents of the sample and solve the 3D atomic structures of the embedded protein molecules in their near-native states.

Sample Preparation
Data Collection
Data Analysis

Our Solutions

Cutting-Edge Cryo-EM
Data Analysis and 3D Reconstruction

Trusted by researchers worldwide, CryoSPARC™ is a powerful, end-to-end platform for single-particle cryo-EM, combining cutting-edge 3D reconstruction algorithms with an intuitive, streamlined workflow. From motion correction to atomic resolution, CryoSPARC enables rapid and reliable structure determination of biologically important targets — including challenging samples such as membrane proteins, GPCRs, ion channels, and flexible or heterogeneous complexes.

From microscope to structure, in minutes. CryoSPARC Live™ delivers real-time cryo-EM data processing, quality assessment, and feedback as data is collected — enabling immediate decision-making and optimization. Whether during acquisition or post-session, CryoSPARC Live™ provides the fastest, most streamlined path to high-resolution structures.

In collaboration with Thermo Fisher Scientific, we’ve developed Embedded CryoSPARC Live — a version of CryoSPARC Live™ designed for seamless integration with Thermo Scientific™ cryo-TEM systems. Embedded directly onto microscope hardware, it works in tandem with Thermo Scientific™ CryoFlow™ and Smart EPU software, bringing real-time data analysis directly into your cryo-EM environment.

CryoSPARC™

Trusted by researchers worldwide, CryoSPARC™ is a powerful, end-to-end platform for single-particle cryo-EM, combining cutting-edge 3D reconstruction algorithms with an intuitive, streamlined workflow. From motion correction to atomic resolution, CryoSPARC enables rapid and reliable structure determination of biologically important targets — including challenging samples such as membrane proteins, GPCRs, ion channels, and flexible or heterogeneous complexes.

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CryoSPARC Live™

From microscope to structure, in minutes. CryoSPARC Live™ delivers real-time cryo-EM data processing, quality assessment, and feedback as data is collected — enabling immediate decision-making and optimization. Whether during acquisition or post-session, CryoSPARC Live™ provides the fastest, most streamlined path to high-resolution structures.

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Embedded CryoSPARC™ Live

In collaboration with Thermo Fisher Scientific, we’ve developed Embedded CryoSPARC Live — a version of CryoSPARC Live™ designed for seamless integration with Thermo Scientific™ cryo-TEM systems. Embedded directly onto microscope hardware, it works in tandem with Thermo Scientific™ CryoFlow™ and Smart EPU software, bringing real-time data analysis directly into your cryo-EM environment.

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Careers

Shape the Future of Cryo-EM with Us

Be part of a pioneering team advancing cryo-EM technology—bring your expertise and grow with us.

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